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KMID : 0363620140350040001
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Journal of Korean Oriental Medicine
2014 Volume.35 No. 4 p.1 ~ p.9
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The Effects of Phragmitis Rhizoma Herbal-acupuncture Solution on Inflammation in Human Mast Cells and Human Alveolar Epithelial Cell Lines - Phragmitis Rhizoma’s Effects -
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Kim Byung-Soo
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Abstract
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Objectives: This study was designed to find the effect of Phragmitis Rhizoma (PR) herbal-acupuncture solution on the inflammatory cytokine and chemokine secretion in human mast cell (HMC) and human alveolar epithelial cell 549 (A549) lines.
Methods: Histamine levels in HMC after PR herbal-acupuncture solution treatment were measured with ELISA. Other cytokines and chemokines levels such as interleukin 8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), and chemokine (C-C motif) ligand 5 (Ccl5, RANTES) in A549 were measured with flow cytometry CBA system.
Results: In the PR herbal-acupuncture solution treatment group, the expression of histamine, IL-8, MPC-1, Ccl5, and RANTES decreased significantly.
Conclusions: The results support that PR herbal-acupuncture solution had a suppressive effect on cytokine-induced inflammation.
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KEYWORD
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Phragmitis Rhizoma, HMC, A549 cell, histamine, cytokine, chemokine
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